Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo.

Authors
Swindells-K; Burnett-N; Rius-Diaz-F; Gonzalez-E; Mihm-MC; Gonzalez-S
Source
J Am Acad Dermatol 2004 Feb; 50(2):220-228
NIOSHTIC No.
20029415
Abstract
BACKGROUND: Acute irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) may be difficult to distinguish by clinical or histologic assessment. Reflectance confocal microscopy (RCM) enables real-time, high-resolution skin imaging in vivo. OBJECTIVE: We sought to image, characterize, and distinguish acute ACD and ICD in vivo. METHODS: Volunteers with ACD were patch tested with an allergen and the irritant, sodium lauryl sulfate. RCM imaging and transepidermal water loss measurements were performed at 24 and 72 hours. Biopsy specimens were correlated with RCM images. RESULTS: Spongiosis, epidermal inflammatory cell infiltrate, and vesicle formation were observed in ACD and ICD. Compared with ACD, ICD showed greater disruption of the stratum corneum, and more parakeratosis. There was a significantly greater increase in transepidermal water loss for ICD compared with ACD. CONCLUSION: RCM is a promising tool for dynamic, noninvasive assessment and may help to differentiate acute ACD and sodium lauryl sulfate-induced ICD.
Keywords
Skin; Skin-diseases; Skin-disorders; Skin-irritants; Skin-lesions; Dermatology; Scanning-techniques; Tissue-disorders; Microscopic-analysis
Contact
Wellman Laboratories of Photomedicine, Massachusetts Geneeral Hospital, Harvard Medical School, Boston, Massachusetts 02114
CODEN
JAADDB
Publication Date
20040201
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004029
Issue of Publication
2
ISSN
0190-9622
Source Name
Journal of the American Academy of Dermatology
State
MA
TOP