Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The mammalian testis-specific thioredoxin system.

Authors
Miranda-Vizuete-A; Sadek-CM; Jimenez-A; Krause-WJ; Sutovsky-P; Oko-R
Source
Antioxid Redox Signal 2004 Feb; 6(1):25-40
NIOSHTIC No.
20029339
Abstract
Redox control of cell physiology is one of the most important regulatory mechanisms in all living organisms. The thioredoxin system, composed of thioredoxin and thioredoxin reductase, has emerged as a key player in cellular redox-mediated reactions. For many years, only one thioredoxin system had been described in higher organisms, ubiquitously expressed in the cytoplasm of eukaryotic cells. However, during the last decade, we and others have identified and characterized novel thioredoxin systems with unique properties, such as organelle-specific localization in mitochondria or endoplasmic reticulum, tissue-specific distribution mostly in the testis, and features novel for thioredoxins, such as microtubule-binding properties. In this review, we will focus on the mammalian testis-specific thioredoxin system that comprises three thioredoxins exclusively expressed in spermatids (named Sptrx-1, Sptrx-2, and Sptrx-3) and an additional thioredoxin highly expressed in testis, but also present in lung and other ciliated tissues (Txl-2). The implications of these findings in the context of male fertility and testicular cancer, as well as evolutionary aspects, will be discussed.
Keywords
Reproductive-system-disorders; Reproductive-system; Spermatogenesis; Spermatozoa; Fertility; Mammalian-cells; Testes
CODEN
ARSIF2
Publication Date
20040201
Document Type
Journal Article
Funding Amount
235845
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R21-OH-007324
Issue of Publication
1
ISSN
1523-0864
Source Name
Antioxidants & Redox Signaling
State
MO
TOP