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The comparative immunotoxicity of five selected compounds following developmental or adult exposure.

Authors
Luebke-RW; Chen-DH; Dietert-R; Yang-Y; King-M; Luster-MI
Source
J Toxicol Environ Health, B 2006 Jan-Feb; 9(1):1-26
NIOSHTIC No.
20029231
Abstract
It is well established that human diseases associated with abnormal immune function, including some common infectious diseases and asthma, are considerably more prevalent at younger ages. Although not established absolutely, it is generally believed that development constitutes a period of increased immune system susceptibility to xenobiotics, since adverse effects may occur at lower doses and/or immunomodulation may be more persistent, thus increasing the relative risk of xenobiotic exposure to the immunologically immature organism. To address this issue, a brief overview of immune maturation in humans is provided to demonstrate that functional immaturity alone predisposes the young to infection. Age-dependent differences in the immunotoxic effects of five diverse compounds, diethylstilbestrol (DES), diazepam (DZP), lead (Pb), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and tributyltin oxide (TBTO), which have undergone adult and developmental immunotoxicity testing in rodents, are then reviewed, as are human data when available. For all five chemicals, the developing immune system was found to be at greater risk than that of the adult, either because lower doses produced immunotoxicity, adverse effects were more persistent, or both.
Keywords
Immunotoxins; Diseases; Immune-system-disorders; Immune-reaction; Humans; Age-factors; Age-groups; Risk-factors; Risk-analysis
CODEN
JTECFR
CAS No.
7439-92-1; 1746-01-6; 56-35-9
Publication Date
20060101
Document Type
Journal Article
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1093-7404
NIOSH Division
HELD
Source Name
Journal of Toxicology and Environmental Health, Part B: Critical Reviews
State
WV; NC; DC
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