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A common polymorphism in XRCC1 as a biomarker of susceptibility for chemically induced genetic damage.

Authors
Li-Y; Marion-MJ; Rundle-A; Brandt-Rauf-PW
Source
Biomarkers 2003 Sep-Oct; 8(5):408-414
NIOSHTIC No.
20029209
Abstract
We have recently demonstrated a significant dose-response relationship between vinyl chloride exposure and mutant p53 biomarkers in humans. The aim of this study was to examine a common polymorphism in the DNA repair gene XRCC1 as a potential biomarker of susceptibility modifying this relationship, consistent with the known mechanism of production of p53 mutations via vinyl chloride-induced etheno-DNA adducts, which are repaired by XRCC1. A cohort of 211 French vinyl chloride workers were genotyped for the XRCC1 codon 399 polymorphism (CGG>CAG; Arg>Gln). Among the homozygous Arg-Arg individuals, 34% were biomarker positive compared with 47% in the heterozygous Arg-Gln individuals (adjusted odds ratio 1.73, 95% CI0.93-3.22) and 66% in the homozygous Gln-Gln individuals (adjusted odds ratio 3.95, 95% CI 1.68-9.28), with a significant trend for increasing Gln allele dosage (p=0.002). These preliminary results suggest that a common polymorphism in a DNA repair gene can be an important biomarker of susceptibility for chemically induced genetic damage.
Keywords
Biomarkers; Dose-response; Humans; Genes; Genetics; DNA-damage; Mutation; Workers; Genetic-factors; Genetic-disorders; Occupational-exposure
CODEN
BIOMFA
CAS No.
75-01-4
Publication Date
20030901
Document Type
Journal Article
Funding Amount
163500
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004192
Issue of Publication
5
ISSN
1354-750X
Source Name
Biomarkers
State
NY
Performing Organization
Department of Environmental Health Sciences, The Mailman School of Public Health, Columbia University, New York, New York
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