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Association of expired nitric oxide with occupational particulate exposure.

Authors
Kim-JY; Wand-MP; Hauser-R; Mukherjee-S; Herrick-RF; Christiani-DC
Source
Environ Health Perspect 2003 May; 111(5):676-680
NIOSHTIC No.
20029206
Abstract
Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (F(E)NO) and exposure to particulate matter with an aerodynamic mass median diameter of less than or equal to 2.5 micro m (PM(2.5)) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20) or 2000 (n = 14). The Wilcoxon median baseline F(E)NO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM(2.5) 8-hr time-weighted average was 0.56 mg/m(3) (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m(3) (95% CI: 0.65, 1.07) in 2000. F(E)NO levels during the work week were significantly lower than baseline F(E)NO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed F(E)NO and the previous workday's PM(2.5) concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m(3) incremental increase in PM(2.5) exposure, log F(E)NO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM(2.5) exposure and F(E)NO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in F(E)NO in a survey of workers with limited respirator usage.
Keywords
Occupational-exposure; Particulates; Pollutants; Pollution; Airborne-particles; Occupational-health; Respiratory-system-disorders; Pulmonary-system-disorders; Metals; Metal-fumes; Metal-dusts; Metal-compounds; Oils; Fly-ash; Exposure-levels; Exposure-assessment; Epidemiology
Contact
D.C. Christiani, Harvard School of Public Health, Occupational Health Program, Bldg. I, Rm. 1402, 665 Huntington Ave., Boston, MA 02115 USA
CODEN
EVHPAZ
CAS No.
10102-43-9
Publication Date
20030501
Document Type
Journal Article
Email Address
dchris@hohp.harvard.edu
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000152
Issue of Publication
5
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
MA
Performing Organization
Harvard University, Boston, MA
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