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Equilibrium water sorption in human stratum corneum.

Authors
Kasting-GB; Barai-ND
Source
J Pharm Sci 2003 Aug; 92(8):1624-1631
NIOSHTIC No.
20029201
Abstract
The water content of the stratum corneum (SC) is a key factor in skin barrier homeostasis; it is intimately related to both skin condition and skin permeability. Studies of water uptake in excised human SC show strong similarities and allow characterization of the equilibrium SC water sorption isotherm in terms of widely used theoretical models. At low water activities, SC water sorption resembles that in other keratinized tissues (i.e., wool and horn), whereas at high water activities, it resembles that in polymeric hydrogels. In this paper, theoretical water sorption models [Brunauer-Emmett-Teller (BET), D'Arcy-Watt, and Frenkel-Halsey-Hill] are fit to the combined human SC water sorption data from our laboratories and others. Each of these models provides a satisfactory description of the equilibrium water content of human SC over the water activity range 0.03-1.0. An accompanying paper discusses the implications of SC water sorption on water mobility in corneocytes and on SC permeability.
Keywords
Water-analysis; Skin; Models; Humans; Skin-absorption; Metabolism; Physiology; In-vitro-study
Contact
Gerald B. Kasting, College of Pharmacy, The University of Cincinnati, PO Box 670004, Cincinnati, Ohio 45267-0004, USA
CODEN
JPMSAE
Publication Date
20030801
Document Type
Journal Article
Email Address
Gerald.Kasting@uc.edu
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007529
Issue of Publication
8
ISSN
0022-3549
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Journal of Pharmaceutical Sciences
State
OH
Performing Organization
University of Cincinnati
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