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Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal.

Authors
Huang-X
Source
Mutat Res 2003 Dec; 533(1-2):153-171
NIOSHTIC No.
20029191
Abstract
Unlike arsenic, chromium, or nickel, the carcinogenicity of iron is still under debate. In this review, evidence for iron as a carcinogenic metal was summarized from epidemiological, animal, and cell culture studies. The role of iron in various cancers, such as colorectal cancer and liver cancer was presented. Recent advancements on the molecular mechanisms of iron carcinogenesis were also reviewed. These include: (1) iron autoxidation involving only Fe(2+)+O2 in oxidant formation in biological systems and its pH dependency; (2) activation of oxidative responsive transcription factors and pro-inflammatory cytokines; and (3) iron-induced hypoxia signaling.
Keywords
Cancer; Humans; Risk-factors; Risk-analysis; Metal-compounds; Metals; Iron-compounds; Carcinogenicity; Carcinogenesis; Carcinogens; Cell-cultures; Epidemiology; Animals; Animal-studies
Contact
Department of Environmental Medicine, NYU Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
CODEN
MUREAV
CAS No.
7439-89-6
Publication Date
20031210
Document Type
Journal Article
Email Address
xihuang@env.med.nyu.edu
Funding Amount
638746
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003561
Issue of Publication
1-2
ISSN
0027-5107
Source Name
Mutation Research
State
NY
Performing Organization
New York University Medical Center, New York, New York
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