Cognitive effects of chronic exposure to lead and solvents.
Fiedler-N; Weisel-C; Lynch-R; Kelly-McNeil-K; Wedeen-R; Jones-K; Udasin-I; Ohman-Strickland-P; Gochfeld-M
Am J Ind Med 2003 Jun; 44(4):413-423
Background Occupational exposure to lead and solvents has declined steadily over the past 20 years, however, construction workers continue to be exposed to these neurotoxicants. The purpose of this study was to investigate the cognitive effects of chronic occupational exposure to lead and solvents. Method Based on K-XRFof tibial bone lead and occupational history of solvent exposure, subjects were classified into four exposure groups: lead (Nž40), solvent (Nž39), lead/ solvent (Nž45), and control (Nž33). All subjects completed tests to assess concentration, motor skills, memory, and mood. Results Relative to controls, the lead, solvent, and lead/solvent groups performed significantly more poorly on a test of verbal memory, while the lead and lead/solvent groups were slower than the solvent and control groups on a task of processing speed. Bone lead was a significant predictor of information processing speed and latency of response while solvent exposure was a significant predictor of verbal learning and memory. Conclusions Bone lead was associated with slower speed of processing while exposure to lead and/or solvents reduced efficiency of verbal learning.
Lead-compounds; Lead-dust; Lead-fumes; Solvents; Occupational-exposure; Neurotoxic-effects; Neurotoxins; Neurotoxicity; Neurotoxicology; Chemical-indicators; Chemical-properties; Mental-processes; Physiological-response; Psychological-reactions; Psychological-responses; Construction; Construction-workers; Motion-studies; Neuromotor-function; Neuromotor-disorders; Neuromotor-system-disorders; Neuromuscular-function; Neuromuscular-system; Neuromuscular-system-disorders
Nancy Fiedler, UMDNJ-RWJ Medical School, 170 Frelinghuysen Road, Room 210, Piscataway, NJ 08854
American Journal of Industrial Medicine
University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Environmental and Occupational Health Sciences Institute