Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Persistent hyperreactivity and reactive airway dysfunction in firefighters at the World Trade Center.

Authors
Banauch-GI; Alleyne-D; Sanchez-R; Olender-K; Cohen-HW; Weiden-M; Kelly-KJ; Prezant-DJ
Source
Am J Respir Crit Care Med 2003 Jul; 168(1):54-62
NIOSHTIC No.
20029136
Abstract
New York City Fire Department rescue workers experienced massive exposure to airborne particulates at the World Trade Center site. Aims of this longitudinal study were to (1) determine if bronchial hyperreactivity was present, persistent, and independently associated with exposure intensity, (2) identify objective measures shortly after the collapse that would predict persistent hyperreactivity and a diagnosis of reactive airways dysfunction 6 months post-collapse. A representative sample of 179 rescue workers stratified by exposure intensity (high, moderate, and control) without current smoking or prior respiratory disease was enrolled. Highly exposed workers arrived within 2 hours of collapse, moderately exposed workers arrived later on Days 1-2; control subjects were not exposed. Hyperreactivity at 1, 3, and 6 months post-collapse was associated with exposure intensity, independent of ex-smoking and airflow obstruction. Six months post-collapse, highly exposed workers were 6.8 times more likely than moderately exposed workers and control subjects to be hyperreactive (95% confidence interval, 1.8-25.2; p = 0.004), and hyperreactivity persisted in 55% of those hyperreactive at 1 and/or 3 months. In highly exposed subjects, hyperreactivity 1 or 3 months post-collapse was the sole predictor for reactive airways dysfunction (p = 0.021). In conclusion, development and persistence of hyperreactivity and reactive airways dysfunction were strongly and independently associated with exposure intensity. Hyperreactivity shortly post-collapse predicted reactive airways dysfunction at 6 months in highly exposed workers; this has important implications for disaster management.
Keywords
Airway-obstruction; Airway-resistance; Fire-fighters; Fire-fighting; Rescue-workers; Occupational-exposure; Airborne-particles; Airborne-dusts; Sampling; Sampling-methods; Exposure-levels; Exposure-assessment; Inorganic-compounds; Particulates; Particulate-dust
Contact
Dr. David Prezant, M.D., Professor of Medicine, Montefiore Medical Center, Pulmonary Division, Centennial 423, Bronx, NY 10467
CODEN
AJCMED
Publication Date
20030701
Document Type
Journal Article
Email Address
Prezd@dnamail.com
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007350; Cooperative-Agreement-Number-U10-OH-008243; Cooperative-Agreement-Number-U10-OH-008242
Issue of Publication
1
ISSN
1073-449X
Source Name
American Journal of Respiratory and Critical Care Medicine
State
NY
TOP