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Genetic factors and asthma in aluminum smelter workers.

Authors
Arnaiz-NO; Kaufman-JD; Daroowala-FM; Quigley-S; Farin-F; Checkoway-H
Source
Arch Environ Health 2003 Apr; 58(4):197-200
NIOSHTIC No.
20029135
Abstract
An asthma-like condition has been reported among aluminum smelter potroom workers. The pathophysiologic mechanisms and the causative agent involved are unknown. Inasmuch as gene polymorphisms are associated with asthma in the general population, the authors of this case-control study examined whether polymorphisms were associated with the development of potroom asthma. Genotyping was performed for the beta2-adrenoreceptor, high-affinity Ig (immunoglobulin) E receptor, and Tumor Necrosis Factor on potroom workers who developed a new asthma-like condition and on individuals who did not develop respiratory problems. No associations were found between potroom asthma case status and genotype. The asthma-like condition associated with potroom work remains poorly understood. Future investigations of genetic susceptibility and occupational asthma may provide pathophysiologic insights into these work-related conditions, but larger numbers of subjects will be required.
Keywords
Genetic-factors; Genetics; Bronchial-asthma; Workers; Aluminum-compounds; Aluminum-industry; Smelters; Smelting; Case-studies; Occupational-exposure; Occupational-diseases; Workplace-monitoring; Workplace-studies
CODEN
AEHLAU
CAS No.
7429-90-5
Publication Date
20030401
Document Type
Journal Article
Funding Amount
1090072
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003445
Issue of Publication
4
ISSN
0003-9896
Source Name
Archives of Environmental Health
State
WA
Performing Organization
University of Washington Department of Enviromental Health, Seattle, Washington
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