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Truncating the dose range for methacholine challenge tests: three occupational studies.

Authors
Agalliu-I; Eisen-EA; Hauser-R; Redlich-CA; Stowe-MH; Cullen-MR; Wegman-DH; Christiani-DC; Kennedy-SM
Source
J Occup Environ Med 2003 Aug; 45(8):841-847
NIOSHTIC No.
20029132
Abstract
The methacholine challenge test protocol was assessed in the reanalysis of three occupational studies. We evaluated the impact of truncating the range of methacholine on responsiveness, as defined by slope and PC(20). In original analysis, reactivity was similar for apprentices and auto body shop workers, whereas boilermakers were more responsive. Truncating high concentrations did not change the classification of subjects with PC(20) <8 or 16 in any population. However, when responsiveness was measured by slope, the mean responsiveness increased, from -7.9 to -15.3 for apprentices and -7.2 to -10.0 for auto-body shop workers. Results support the American Thoracic Society's recommended maximum of 16 mg/ml and provide evidence that extending the dose range beyond that does not increase sensitivity, whereas stopping before 16 may exaggerate response. Furthermore, to ensure validity, neither slope nor PC(20) should be extrapolated beyond data.
Keywords
Methacholines; Automobile-repair-shops; Automotive-industry; Workers; Mathematical-models; Injuries; Diseases; Occupational-exposure; Occupational-diseases
CODEN
JOEMFM
Publication Date
20030801
Document Type
Journal Article
Funding Amount
2634676
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003457; Grant-Number-R01-OH-000152
Issue of Publication
8
ISSN
1076-2752
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Journal of Occupational and Environmental Medicine
State
CT; MA
Performing Organization
Yale University, New Haven, Connecticut
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