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Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine.

Authors
Baynes-RE; Yeatts-JL; Brooks-JD; Riviere-JE
Source
Toxicol Lett 2005 Dec; 159(3):252-260
NIOSHTIC No.
20029131
Abstract
Triazine is often added to cutting-fluid formulations in the metal-machining industry as a preservative. Trichloroethylene (TCE) is a solvent used for cleaning the cutting fluid or oil from the metal product. The purpose of this study was to examine the effect of TCE on the dermal absorption of triazine in an in vitro flow-through diffusion cell system. Skin sections were dosed topically with aqueous mixtures containing mineral oil or polyethylene glycol (PEG) spiked with (14)C-triazine. Some skin sections were simultaneously exposed to TCE while other skin sections were pre-treated with TCE daily for 4 days in vivo and then exposed to these mixtures in vitro. TCE pre-treatment almost doubled triazine permeability, but this pre-treatment had no effect on triazine diffusivity. The pre-treatment effects of TCE on triazine permeability appear to be more important in PEG-based mixtures than in the mineral oil-based mixtures. Simultaneous single exposure to TCE had little or no effect on triazine absorption. TCE absorption was significantly less than triazine absorption; however, cutting fluid additives had a more significant effect on TCE absorption than on triazine absorption. In summary, this study demonstrated that TCE pre-treatment can significantly alter the dermal permeability to triazine, and workers who are chronically exposed to this or similar cleansers may be at increased risk of absorbing related skin irritants.
Keywords
Triazines; Biocides; Metals; Solvents; Skin; Skin-exposure; In-vitro-studies; In-vivo-studies; Skin-irritants
CODEN
TOLED5
CAS No.
79-01-6
Publication Date
20051215
Document Type
Journal Article
Email Address
Ronald.Baynes@ncsu.edu
Funding Amount
875919
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003669
Issue of Publication
3
ISSN
0378-4274
Priority Area
Disease and Injury: Allergic and Irritant Dermatitis
Source Name
Toxicology Letters
State
NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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