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NDELA and nickel modulation of triazine disposition in skin.

Authors
Baynes-RE; Brooks-JD; Barlow-BM; Riviere-JE
Source
Toxicol Ind Health 2005 Oct; 21(9):197-205
NIOSHTIC No.
20029130
Abstract
Cutting fluids can become contaminated with metals (e.g., nickel, Ni) and nitrosamines (e.g., N-nitrosodiethanolamine, NDELA) and there is concern that these classes of contaminants can modulate dermal disposition and ultimately the toxicity of cutting fluid additives, such as irritant biocides (e.g., triazine). Biocides are added to these formulations to prevent bacterial degradation of commercial cutting fluids. The purpose of this study was to assess the dermal absorption and skin deposition of 14C-triazine when topically applied to porcine skin in an in vitro flow-through diffusion cell system as aqueous soluble oil (mineral oil, MO) or aqueous synthetic (polyethylene glycol, PEG) mixtures. 14C-Triazine mixtures were formulated with NDELA and/or Ni, or with a combination of three additional cutting fluid additives; namely, 5% linear alkylbenzene sulfonate (LAS), 5% triethanolamine (TEA) and 5% sulfurized ricinoleic acid. Neither Ni nor NDELA was absorbed during these 8-h studies. However, 14C-triazine absorption ranged from 2.72 to 3.29% dose in MO and 2.29-2.88% dose in PEG with significantly greater triazine absorption in MO than PEG when all additives and contaminates were present. The difference between these two diluents was most pronounced when NDELA and/or Ni were present in cutting fluids. These contaminants also enhanced triazine deposition on the skin surface and skin tissues especially with PEG-based mixtures. In essence, the dermal disposition of irritant biocides could be dependent on whether the worker is exposed to a soluble oil or synthetic fluid when these contaminants are present. Workers should therefore not only be concerned about dermatotoxicity of these contaminants, but also the modulated dermal disposition of cutting fluid additives when these contaminants are present in cutting fluid formulations.
Keywords
Nickel-compounds; Triazines; Metals; Biocides; Toxins; Toxic-effects; Skin; Skin-irritants; Occupational-exposure; Workers
CODEN
TIHEEC
CAS No.
7440-02-0
Publication Date
20051001
Document Type
Journal Article
Email Address
Ronald_Baynes@ncsu.edu
Funding Amount
875919
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003669
Issue of Publication
9
ISSN
0748-2337
Priority Area
Disease and Injury: Allergic and Irritant Dermatitis
Source Name
Toxicology and Industrial Health
State
NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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