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Vibration-induced disruption of retrograde axoplasmic transport in peripheral nerve.

Authors
Yan-JG; Matloub-HS; Sanger-JR; Zhang-LL; Riley-DA
Source
Muscle Nerve 2005 Oct; 32(4):521-526
NIOSHTIC No.
20029072
Abstract
Hand-arm vibration syndrome (HAVS) results from excessive exposure to hand-transmitted vibration. Whether the peripheral nerve damage characteristic of HAVS is a direct result of vibration or is secondary to vascular insufficiency remains unclear. The purpose of this study was to explore the effect of vibration exposure on axoplasmic transport in peripheral nerves and soleus motor neurons. Sciatic nerves and motor neurons from rats following two 5-h periods of vibration exposure demonstrated disruption in retrograde transport compared to normal. After 10 days of vibration (5 h/day), axoplasmic transport failed to recover within 24-48 h in most rats. This study demonstrates that disrupted axoplasmic transport is an early consequence of short-term vibration exposure. The effects of vibration on axoplasmic transport also appear to be cumulative. This study provides a new biological way to evaluate measures to prevent early vibration injury.
Keywords
Vibration-exposure; Vibration-effects; Vibration-disease; Neuropathy; Vibration; Hand-injuries; Arm-injuries; Diseases; Occupational-exposure; Nerve-damage; Injuries; Injury-prevention
Contact
Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
CODEN
MUNEDE
Publication Date
20051001
Document Type
Journal Article
Email Address
hmatloub@mcw.edu
Funding Amount
922402
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003493
Issue of Publication
4
ISSN
0148-639X
Priority Area
Other Occupational Concerns
Source Name
Muscle and Nerve
State
WI
Performing Organization
Medical College of Wisconsin, Milwaukee, Wisconsin
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