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In vivo reflectance-mode confocal scanning laser microscopy in dermatology.

Authors
Gonzalez-S; Gilaberte-Calzada-Y; Gonzalez-Rodriguez-A; Torres-A; Mihm-MC-Jr
Source
Adv Dermatol 2004 Jan; 20:371-387
NIOSHTIC No.
20029067
Abstract
RCM offers tremendous potential for the advancement of medical research and clinical care. In research, it offers benefits both ex vivo and in vivo. Ex vivo, it can allow us to sample tissue and evaluate it noninvasively to determine what further testing--on the same exact tissue--may be helpful. In vivo RCM can be used to study normal or pathophysiologic processes in real-time noninvasively and by the same technique sequentially over time. Immunologic events previously only studied ex vivo or by static images can be traced from their inception to completion (Table 1). The potential of RCM in vivo is tremendous. How would our world change if we could noninvasively diagnose skin lesions and, with the advent of new minimally invasive therapies, administer treatment and noninvasively monitor that treatment? The potential to allow better medical care based on actual visualization of therapeutic response and healing is obvious. Much like early X-ray and ultrasound imaging, RCM is in its infancy. It is only a matter of time and continued persistent research that will lead to similar success and utility for RCM.
Keywords
Skin; Skin-diseases; Skin-disorders; Skin-irritants; Skin-lesions; Dermatology; Scanning-techniques; Tissue-disorders; Ultrasound
Contact
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
CODEN
ADDEEK
Publication Date
20040101
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004029
ISSN
0882-0880
Source Name
Advances in Dermatology
State
MA
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