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Promotion of noise-induced hearing loss by chemical contaminants.

Authors
Fechter-LD
Source
J Toxicol Environ Health, A 2004 Apr; 67(8-10):727-740
NIOSHTIC No.
20029059
Abstract
Recent studies have underscored the ability of a wide range of chemical agents to potentate noise-induced hearing loss. Given the ubiquitous nature of noise exposure particularly in many work settings, the high rate of noise-induced hearing loss, the limited degree to which auditory function can recover following damage to the inner ear, and the disparate chemical structures that appear capable of impairing hearing, this issue appears to have great public health significance. A compendium of chemicals known to potentiate noise induced hearing loss is presented along with a hypothesis that might explain at least one basis for potentiation of noise-induced hearing loss by certain chemical toxicants. The use of benchmark dose analysis to undertake a risk assessment for promotion of noise-induced hearing loss by both carbon monoxide and hydrogen cyanide is described.
Keywords
Hearing-protection; Noise-induced-hearing-loss; Synergistic-effects; Organic-solvents; Ototoxicity
Contact
Research Service, Jerry Pettis Memorial Veterans Medical Center, Loma Linda Veterans Association for Research and Education, Loma Linda, California
CODEN
JTEHD6
Publication Date
20040423
Document Type
Journal Article
Email Address
larry.fechter@med.va.gov
Funding Amount
561752
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003481
Issue of Publication
8-10
ISSN
1528-7394
Priority Area
Disease and Injury: Hearing Loss
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
CA; OK
Performing Organization
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma
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