Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Occupational and environmental exposures as risk factors for systemic lupus erythematosus.

Authors
Cooper-GS; Parks-CG
Source
Curr Rheumatol Rep 2004 Oct; 6(5):367-374
NIOSHTIC No.
20029013
Abstract
Although genetic susceptibility plays a strong role in the etiology of systemic lupus erythematosus (SLE), recent research has provided new evidence of the potential influence of environmental factors in the risk for this disease. This paper describes epidemiologic and experimental research pertaining to occupational and environmental sources of exposure to respirable crystalline silica, solvents and pesticides, and two "lifestyle" factors (smoking and hair dye use). As has been seen with other systemic autoimmune diseases (eg, systemic sclerosis and rheumatoid arthritis), a series of epidemiologic studies, using different designs in different settings, have demonstrated relatively strong and consistent associations between occupational silica exposure and SLE. The type and quality of exposure assessment is an important consideration in evaluating these studies. Recent experimental studies examined the effect of trichloroethylene exposure in MRL+/+ mice, but to date there have been few epidemiologic studies of solvents and SLE. There are numerous avenues with respect to environmental factors in SLE that need additional research.
Keywords
Occupational-exposure; Environmental-exposure; Risk-factors; Etiology; Diseases; Epidemiology; Silica-dusts; Silicates; Solvents; Pesticides; Exposure-assessment; Laboratory-animals; Environmental-factors; Animals; Animal-studies
Contact
Epidemiology Branch MDA3-05, National Institute of Environmental Health Sciences, PO Box 12233, Durham, NC 27709, USA
CAS No.
14808-60-7
Publication Date
20041001
Document Type
Journal Article
Email Address
cooper1@niehs.nih.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1523-3774
NIOSH Division
HELD
Source Name
Current Rheumatology Reports
State
WV
TOP