Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: The Honolulu-Asia Aging Study.

Authors
Yucesoy-B; Peila-R; White-LR; Wu-KM; Johnson-VJ; Kashon-ML; Luster-MI; Launer-LJ
Source
Neurobiol Aging 2006 Feb; 27(2):211-217
NIOSHTIC No.
20029000
Abstract
The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1alpha, IL-1Beta and the IL-1 receptor antagonist (RN) and their genotype associations with late-onset AD and VaD were determined in a Japanese-American cohort of men (n = 931) participating in the Honolulu-Asia Aging Study (HAAS). A significant association was found between the IL-1Beta (-511) and IL-1RN (+2018) polymorphisms and AD, suggesting that these variants confer an increased risk. Possessing the IL-1Beta (-511) T/T genotype was also associated with VaD. There was no difference in the IL-1Beta (+3953) frequency among the groups. Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia.
Keywords
Central-nervous-system; Central-nervous-system-disorders; Neurological-system; Neurological-diseases; Nervous-system-disorders; Neurophysiology
Contact
Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
NEAGDO
Publication Date
20060201
Document Type
Journal Article
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0197-4580
NIOSH Division
HELD
Source Name
Neurobiology of Aging
State
WV
TOP