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Neuropathological changes in vibration injury: an experimental study.

Authors
Matloub-HS; Yan-JG; Kolachalam-RB; Zhang-LL; Sanger-JR; Riley-DA
Source
Microsurgery 2005 Jan; 25(1):71-75
NIOSHTIC No.
20028868
Abstract
Vibration syndrome, a clinical condition arising from chronic use of vibrating tools, is associated with a spectrum of neurovascular symptoms. To date, only its vascular pathology has been extensively studied; we sought to determine what direct neurologic injury, if any, is caused by vibration. Hindlimbs of anesthetized rats were affixed to a vibrating platform 4 h a day for 7 days. Study animals were vibrated with set parameters for frequency, acceleration, velocity, and amplitude; control animals were not vibrated. On day 7, nerves were studied by light and electron microscopy. While light microscopy showed minimal histologic differences between vibrated (n=12) and control (n=12) nerves, electron microscopic changes were dramatic. Splitting of the myelin sheath and axonal damage (e.g., myelin balls and "finger ring") were consistently seen in both myelinated and nonmyelinated axons. Despite relatively short vibration, definite pathology was demonstrated, suggesting that vibration syndrome has a direct neurologic component.
Keywords
Neuropathology; Injuries; Vibration; Vibration-exposure; Vibration-effects; Neurovascular-disorders; Laboratory-animals; Animals; Animal-studies
Contact
Hani S. Matloub, Department of Plastic Surgery, 8700 Watertown Plank Road, Milwaukee, WI 53226
Publication Date
20050101
Document Type
Journal Article
Email Address
hmatloub@mcw.edu
Funding Amount
922402
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003493
Issue of Publication
1
ISSN
0738-1085
Priority Area
Other Occupational Concerns
Source Name
Microsurgery
State
WI
Performing Organization
Medical College of Wisconsin, Milwaukee, Wisconsin
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