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p53 autoantibodies predict subsequent development of cancer.

Authors
Li-Y; Karjalainen-A; Koskinen-H; Hemminki-K; Vainio-H; Shnaidman-M; Ying-Z; Pukkala-E; Brandt-Rauf-PW
Source
Int J Cancer 2005 Mar; 114(1):157-160
NIOSHTIC No.
20028856
Abstract
Because TP53 mutations can induce an immune response and can occur early in the carcinogenic process for some tumors, p53 autoantibodies may be useful biomarkers for risk of development of cancer. Using banked serum samples from an asbestosis cohort at high risk for cancer, we demonstrate for the first time a statistically significant relationship between p53 autoantibodies and the subsequent development of malignancy (hazard ratio [HR] = 5.5, 95% confidence interval [CI] = 2.8-10.9) with a positive predictive value of 0.76 and an average lead time to diagnosis of 3.5 years. p53 autoantibodies were also significantly associated with p53 alterations in the resultant tumors (kappa = 0.78, p = 0.01).
Keywords
Cancer; Biomarkers; Immune-reaction; Tumors; Risk-factors; Risk-analysis; Carcinogens; Carcinogenesis; Carcinogenicity
Contact
Paul W. Brandt-Rauf, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, New York, NY 10032
CODEN
IJCNAW
Publication Date
20050301
Document Type
Journal Article
Email Address
pwb1@columbia.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007590
Issue of Publication
1
ISSN
0020-7136
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
International Journal of Cancer
State
NY
Performing Organization
Columbia University Health Sciences
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