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Tumor necrosis factor-alpha hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmers.

Authors
Lambert-GP; Spurzem-JR; Romberger-DJ; Wyatt-TA; Lyden-E; Stromquist-AM; Merchant-JA; Von Essen-S
Source
J Agromed 2005 Jan; 10(1):39-44
NIOSHTIC No.
20028839
Abstract
Many farmers experience chronic bronchitis, airflow obstruction, and asthma. It is thought that these respiratory problems may be related to workplace inhalation of organic dust containing endotoxin. The purpose of this study was to determine whether whole blood cytokine responsiveness to endotoxin is associated with airflow disorders (i.e., airflow obstruction, chronic bronchitis, and doctor-diagnosed asthma). Farmers (N = 95) were recruited from a rural cohort study and completed a respiratory symptom and history questionnaire, spirometry, and blood sampling. Blood was incubated 24 hours in the presence and absence of endotoxin and supernatants were analyzed for TNF-alpha, IL-1beta, IL-6, and IL-8. Hypo- or hyper-responsiveness to endotoxin was based on whether cytokine values were in the lower or upper 10% of the group range, respectively. A significant association existed between TNF-alpha hyper-responsiveness and chronic bronchitis. These results indicate that the whole blood cytokine assay may be useful to identify individual responsiveness to endotoxin, and may provide an additional diagnostic tool to evaluate persons potentially at risk for developing chronic bronchitis following exposure to organic dust in the workplace.
Keywords
Farmers; Bronchial-asthma; Airway-obstruction; Respiratory-system-disorders; Agriculture; Agricultural-workers; Agricultural-industry; Questionnaires; Spirometry; Blood-sampling; Occupational-exposure; Exposure-levels; Exposure-assessment; Organic-dusts; Endotoxins
Publication Date
20050101
Document Type
Journal Article
Email Address
plambert@creighton.edu
Funding Type
Cooperative Agreement; Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007548; Grant-Number-T42-OH-008491
Issue of Publication
1
ISSN
1059-924X
Source Name
Journal of Agromedicine
State
NE; IA
Performing Organization
University of Iowa
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