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Dermal capillary clearance: phsysiology and modeling.

Authors
Kretsos-K; Kasting-GB
Source
Skin Pharmacol Physiol 2005 Mar-Apr; 18(2):55-74
NIOSHTIC No.
20028836
Abstract
Substances applied to the skin surface may permeate deeper tissue layers and pass into the body's systemic circulation by entering blood or lymphatic vessels in the dermis. The purpose of this review is an in-depth analysis of the dermal clearance/exchange process and its constituents: transport through the interstitium, permeability of the microvascular barrier and removal via the circulation. We adapt an 'engineering' viewpoint with emphasis on quantifying the dermal microcirculatory physiology, providing the theoretical framework for the physics of key transport processes and reviewing the available computational clearance models in a comparative manner. Selected experimental data which may serve as valuable input to modeling attempts are also reported.
Keywords
Physiology; Models; Skin; Skin-exposure; Computer-models; Blood-vessels; Lymphatic-system
Contact
Kosmas Kretsos, College of Pharmacy, 3223 Eden Avenue, University of Cincinnati Medical Center, PO Box 67004, Cincinnati, OH 45267-0004, USA
CODEN
SPAPFF
Publication Date
20050301
Document Type
Journal Article
Email Address
Kosmas.Kretsos@uc.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007529
Issue of Publication
2
ISSN
1660-5527
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Skin Pharmacology and Physiology
State
NY; OH
Performing Organization
University of Cincinnati
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