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Nifedipine pretreatment reduces vibration-induced vascular damage.

Authors
Curry-BD; Govindaraju-SR; Bain-JL; Zhang-LL; Yan-JG; Matloub-HS; Riley-DA
Source
Muscle Nerve 2005 Nov; 32(5):639-646
NIOSHTIC No.
20028790
Abstract
A rat-tail vibration model of hand-arm vibration was employed to test whether preemptive administration of nifedipine (5 mg/kg) to block vasoconstriction prevents vibration-induced arterial damage. The tails of vibrated and nifedipine-pretreated vibrated Sprague-Dawley rats were exposed continuously to 4 h of 60-HZ vibration at 49 m/s(2) rms. In nonvibrated anesthetized rats, the ventral tail arteries were bathed for 15 min in situ in 1 mM epinephrine or 1 mM norepinephrine to induce structural changes indicative of intense vasoconstriction. Arteries were processed for light and electron microscopy 45 min after treatment. Compared to sham control, 4-h vibration significantly (P < 0.01) reduced lumen size, generated endothelial disruption (7.0 +/- 2.6%), elevated nuclear factor of activated T cells c3 (NFATc3) expression in endothelial and smooth muscle cells, and increased smooth muscle cell vacuolization. The findings demonstrate that blockage of vibration-induced vasoconstriction with nifedipine prevents acute vascular damage. Smooth muscle and endothelial cells structurally altered by vasoconstriction are rendered susceptible to damage by vibration.
Keywords
Hand-injuries; Arm-injuries; Vibration; Laboratory-animals; Animals; Animal-studies; Exposure-levels; Exposure-assessment; Vibration-effects; Vibration-exposure; Neurovascular-disorders
Contact
Danny A. Riley, Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
CODEN
MUNEDE
Publication Date
20051101
Document Type
Journal Article
Email Address
dariley@mcw.edu
Funding Amount
922402
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003493
Issue of Publication
5
ISSN
0148-639X
Priority Area
Other Occupational Concerns
Source Name
Muscle & Nerve
State
WI
Performing Organization
Medical College of Wisconsin, Milwaukee, Wisconsin
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