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Melatonin, sleep, and shift work adaptation.

Authors
Burch-JB; Yost-MG; Johnson-W; Allen-E
Source
J Occup Environ Med 2005 Sep; 47(9):893-901
NIOSHTIC No.
20028719
Abstract
Night work is associated with disrupted circadian rhythms, fatigue, accidents, and chronic disease. Melatonin secretion helps regulate sleep and circadian rhythms. Melatonin, sleep disturbances, and symptoms (sleep, fatigue, mental) were compared among workers on permanent day, swing, and night shifts. Urinary 6-hydroxymelatonin sulfate (6-OHMS) was measured in postwork and postsleep samples. Disrupted circadian melatonin production was evaluated using the sleep:work 6-OHMS ratio. Wrist actigraphy characterized light exposures and sleep characteristics. Night workers had altered melatonin, disrupted sleep, and elevated symptom prevalence. Subjects grouped by their sleep:work 6-OHMS ratio rather than shift had even greater symptom prevalence. Risks for two or more symptoms were 3.5 to 8 times greater among workers with sleep:work ratios < or =1 compared to those with ratios >1. This ratio may help identify workers at increased risk for accidents or injuries.
Keywords
Shift-work; Shift-workers; Fatigue; Occupational-accidents; Accidents; Diseases; Sleep-disorders; Sleep-deprivation; Sampling; Risk-analysis; Risk-factors; Injuries; Circadian-rhythms
CODEN
JOEMFM
Publication Date
20050901
Document Type
Journal Article
Email Address
burch@gwm.sc.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003885
Issue of Publication
9
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
CO
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