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Methodologic issues concerning stachyhemolysin and stachyrase-A as clinical biomarkers.

Authors
Page-EH; Biagini-RE; Beezhold-DH
Source
Med Sci Monit 2005 Sep; 11(9):LE7-LE8
NIOSHTIC No.
20028434
Abstract
We are writing about the recently published article "Antibodies against Stachybotrys chartarum extract and its antigenic components, Stachyhemolysin and Stachyrase-A: a new clinical biomarker" [1]. The author states that his hypothesis is "that environmental exposure to Stachyhemolysin and Stachyrase-A may result in antibody production against these mold antigens." There are numerous methodologic defi ciencies in this paper which preclude drawing any conclusions regarding the utility of anti-stachyhemolsyin and anti-stachyrase-A antibodies as biomarkers. In closing, we feel there are signifi cant problems with this paper which preclude the author's conclusions that antibodies to Stachyhemolysin and Stachyrase-A are new clinical biomarkers of exposure to Stachybotrys chartarum. The fi ndings and conclusions in this letter to the editor are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
Keywords
Biomarkers; Environmental-exposure; Antibody-response; Exposure-levels; Exposure-assessment; Exposure-limits
CODEN
MSMOFR
Publication Date
20050901
Document Type
Journal Article
Email Address
EPage@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
9
ISSN
1234-1010
NIOSH Division
DSHEFS; DART; HELD
Source Name
Medical Science Monitor
State
WV; OH
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