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The precision of longitudinal lung function measurements: monitoring and interpretation.

Authors
Hnizdo-E; Yu-L; Freyder-L; Attfield-M; Lefante-J; Glindmeyer-HW
Source
Occup Environ Med 2005 Oct; 62(10):695-701
NIOSHTIC No.
20028433
Abstract
The efficacy of decision making based on longitudinal spirometric measurements depends critically on the precision of the available data, which is determined by the magnitude of the within-person variation. Firstly, to describe and investigate two statistical methods-a pairwise estimate of within-person standard deviation s(p) and the reliability coefficient G-for use in the monitoring of precision of longitudinal measurements of forced expiratory volume in one second (FEV1). Secondly, to investigate the effect of longitudinal data precision on the detectable excess rate of decline in FEV1. The authors "monitored" retrospectively on a yearly basis the magnitude of the within-person variation s(p) and the coefficient G in 11 workplace based spirometric monitoring programmes conducted from 1987 to 2001 on 12 729 workers in various industrial plants. The plant-specific mean values s(p) (range 122-166 ml) and G (range 0.88-0.95), averaged over all years of follow up, correlated well with the plant-specific within-person standard deviation s(r) (range 130-177 ml) estimated from all longitudinal data. The correlations were 0.90 for s(p) and 0.68 for G. The average precision of the longitudinal FEV1 measurements affected the duration of follow up needed to identify a "true" excess rate of decline in FEV1 in an individual. The results show that monitoring of longitudinal spirometry data precision (1) allows that data precision can be improved or maintained at levels that allow individuals with a rapid decline to be identified at an earlier age; and (2) attaches a measure of precision to the data on which decision making is based.
Keywords
Lung-function; Spirometry; Monitoring-systems; Pulmonary-system-disorders; Respiratory-system-disorders; Statistical-analysis; Surveillance
Contact
Dr E Hnizdo, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
OEMEEM
Publication Date
20051001
Document Type
Journal Article
Email Address
ehnizdo@cdc.gov
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
1351-0711
NIOSH Division
DRDS
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Occupational and Environmental Medicine
State
WV; LA
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