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Bio-calorimeter system to measure the metabolic rate of laboratory animals after inhalation exposure to toxic materials.

Authors
Goldsmith-WT; McKinney-WG; Huffman-JS; Fedan-JS; Reynolds-JS; Goldsmith-E; Smith-J; Frazer-DG
Source
Am J Respir Crit Care Med 1999 Mar; 159(3)(Suppl):A490
NIOSHTIC No.
20028308
Abstract
Metabolic rate of animals can be affected by a variety of toxic agents. Virtual instrument software was developed to capture and display data provided by a modified direct calorimeter. The calorimeter system was evaluated by examining four groups of rats (n=6) injected with thyroxine(T4) or solvent alone. Half of each group was exposed to ozone (2 ppm for 3 hours) or air. Breathing rates in addition to metabolic rates were measured pre-exposure, immediately post-exposure and 18 hours post-exposure. Metabolic rates were computed following equilibration which occurred in ten to twenty minutes. The calorimeter system provides non-invasive, reproducible results which can be used to evaluate an animal's metabolic response to toxic materials. In addition, the system displays and saves the data in real time and is easily operated.
Keywords
Analytical-processes; Analytical-methods; Animal-studies; Animals; Laboratory-animals; Exposure-assessment; Metabolic-rate; Computer-software
CODEN
AJCMED
Publication Date
19990301
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
1073-449X
NIOSH Division
HELD
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WV; CA
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