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NF-kB, a pivotal transcription factor in silica-induced diseases.

Authors
Chen-F; Shi-X
Source
Mol Cell Biochem 2002 May; 234-235(1):169-176
NIOSHTIC No.
20028117
Abstract
Inhalation of silica in a number of occupational settings can result in debilitating and costly lung disease. It is thought that the pathological replacement of functional lung tissue with fibrotic lesions in silica-induced lung disease is the result of chronic inflammation mediated by products of the silica-exposed alveolar macrophage. In particular, inflammatory cytokines, growth factors and reactive oxygen species have been implicated in many acute and chronic inflammatory lung diseases. Pharmacological intervention to modify the production of these mediators has been shown to ameliorate several of these disease processes. Recent studies have demonstrated that the production of these inflammatory mediators is altered as a result of the activation of nuclear factor-kB (NF-kB). NF-kB is a pivotal transcription factor activated by silica in macrophages and other types of lung cells. The understanding of how silica induces NF-kB activation and what signaling pathways are involved in this silica-induced NF-kB activation is important and should provide valuable new information related to both the etiology and potential treatment of silica-related lung diseases. This review summarizes the molecular mechanisms involved in silica-induced NF-kB activation and discusses the importance of NF-kB as a critical transcription factor in mediating silica-induced lung diseases.
Keywords
Respiratory-system-disorders; Silica-dusts; Lung-disease; Lung-tissue; Cancer; Alveolar-cells; Cytopathology; Cell-damage; Gene-mutation
Contact
National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
MCBIB8
CAS No.
7631-86-9; 14808-60-7
Publication Date
20020501
Document Type
Journal Article
Email Address
Xshi@cdc.gov
Funding Amount
2937066
Funding Type
Cooperative Agreement
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U60-CCU-306149
Issue of Publication
1
ISSN
0300-8177
NIOSH Division
HELD
Source Name
Molecular and Cellular Biochemistry
State
WV
Performing Organization
Center to Protect Workers' Rights
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