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Induction of activator protein-1 (AP-1) by asbestos and the inhibitory effect of aspirin.

Authors
Ding-M
Source
Asbestos Exposure and Disease Control. Soucebook on Asbestos Diseases, Volume 20:. GA Peters and BJ Peters, eds., Carlottesville, VA: LEXIS Law Publishing, 1999 Jan; 20:173-196
Link
NIOSHTIC No.
20028109
Abstract
The following chapter presents what might be an important advance in the treatment and prevention of asbestos-related cancers. Asbestos-induced AP-1 activation, in vitro and in vivo, provides some understanding of the cellular pathology leading to cancer and the mechanisms by which such growth might be inhibited. This chapter indicates that aspirin is just such an inhibitor of the regulating transcription factor AP-1. It suggests the pathways where searches could be made for possible therapeutic agents that might play an important role against asbestos-related malignancies.
Keywords
Analytical-processes; Analytical-methods; Animal-studies; Animals; Laboratory-animals; Carcinogens; Carcinogenicity; Carcinogenesis; Toxins; Toxic-effects; Cancer; Antioxidants; Exposure-assessment; Statistical-analysis; Respiratory-system-disorders; Pulmonary-system-disorders; Cell-cultures; Cell-damage; Cell-function; Cellular-function; Cellular-reactions; Asbestos-dust; Asbestos-fibers; Asbestos-products
CAS No.
50-78-2; 1332-21-4
Publication Date
19990101
Document Type
Book or book chapter
Editors
Peters-GA; Peters-BJ
Fiscal Year
1999
NTIS Accession No.
NTIS Price
ISBN No.
7836031004
NIOSH Division
HELD
Source Name
Asbestos Exposure and Disease Control. Soucebook on Asbestos Diseases, Volume 20
State
WV; VA
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