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Effects of hard metal cationic salts on guinea-pig airway smooth muscle reactivity in vitro.

Authors
Fedan-JS; Cutler-D; Rengasamy-A
Source
Am J Respir Crit Care Med 1999 Mar; 159(3)(Suppl):A619
NIOSHTIC No.
20028085
Abstract
Inhalation of dust from hard metal (HM), a mixture of tungsten carbide (WC), cobalt, and other metals, can cause interstitial alveolitis, fibrosis and asthma. Some effects of HM in the lung could occur after the metals have dissolved and penetrated the tissues. We examined in guinea-pig isolated tracheal strips whether metal salts can affect airway smooth muscle (ASM) reactivity. In unstimulated strips, the chlorides of Ni, Co, Cd evoked weak contractions (> 3 x 10^-6M; 5-15% of 120 mM KCI), while Cr2+, Cr3+, Ta5 and Zn caused relaxations (> 10^-5 M). With methacholine (MCh; 3 x 10^-7 M)-induced tone, Ni and Co caused relaxation in lower concentrations (10-7 M); the others metals caused relaxation only in high concentrations (> 1 Q-4 M). The effects of low (10^-6 M; "L") and high (3 x 10^-4 M; "H") metal concentrations on reactivity to MCh also was assessed. Co and Ta were without any effect on reactivity. Only Cd (H) affected the MCh EC50, and it decreased sensitivity. The metals affected the maximum contraction to MCh as follows: Cd, (down) (L, H); Ni, (up) (L), (down) (H); Cr2+, (down) (L, H); Cr3+, (up) (H); Zn, (up) (H). Thus, some metals (Co, Cd, Ni, Cr3+ and Zn) once dissolved might cause contraction or increase the reactivity of the ASM.
Keywords
Hard-metals; Hard-metal-disease; Airborne-particles; Airborne-dusts; Dust-inhalation; Dust-particles; Dust-analysis; Animal-studies; Laboratory-animals; In-vitro-study; Analytical-methods; Analytical-chemistry; Chemical-analysis; Metal-dusts; Metallic-dusts; Metallic-compounds; Metallic-salts
CODEN
AJCMED
Publication Date
19990301
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
1073-449X
NIOSH Division
HELD
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WV
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