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Changes in F-actin organization induced by hard metal particle exposure in rat pulmonary epithelial cells as observed by laser scanning confocal microscopy.

Authors
Antonini-JM; Starks-K; Roberts-JR; Millecchia-LL; Yang-HM; Rao-KMK
Source
Microsc Microanal 1999 Aug; 5(Suppl 2):492-493
NIOSHTIC No.
20028083
Abstract
Hard metal is an alloy of tungsten carbide and cobalt along with other components such as chromium carbide, molybdenum carbide, tantalum carbide, and nickel. Chronic exposure to hard metal particles by inhalation causes alveolitis leading to interstitial fibrosis, the pathogenesis of which is still undefined. The initial inflammatory response includes a change in epithelial cell permeability barrier function (1) which has been shown to be regulated by the state of assembly and organization of the actin cytoskeletal network (2, 3). Therefore, the objective of this study was to evaluate the effect hard metal particles have on F-actin organization of rat lung epithelial cells in an in vitro culture system.
Keywords
Exposure-levels; Laboratory-animals; Animals; Animal-studies; Pulmonary-system-disorders; Inhalation-studies; Fibrosis; Lung-cells; Metals; Lung-fibrosis; Respiratory-system-disorders; Heavy-metals; Heavy-metal-poisoning; Metal-poisoning; Metal-compounds; Metal-dusts
CODEN
MIMIF7
CAS No.
7440-48-4; 7439-98-7; 7440-02-0
Publication Date
19990801
Document Type
Conference/Symposia Proceedings
Email Address
jga6@cdc.gov
Fiscal Year
1999
NTIS Accession No.
NTIS Price
ISSN
1431-9276
NIOSH Division
HELD
Source Name
Microscopy and Microanalysis
State
WV; OR
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