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Endocrine disruption and neurotoxicity: why toxicologists should be concerned about the actions of estrogenic chemicals in the CNS.

Authors
Miller-DB; Ali-SF
Source
Toxicologist 1999 Mar; 48(1-S):414
NIOSHTIC No.
20028049
Abstract
Susceptibility, whether acquired or innate, can dictate the biological response to a chemical and gender is one, such susceptibility factor. Many toxicological responses have been examined in the context of gender and the recent concern regarding the "hormone-like" properties of certain man-made chemicals has focused interest on how estrogen and chemicals with estrogenic properties can influence toxicological endpoints. Reproductive endpoints, however, have been of primary concern and there has been little examination of neurotoxic endpoints in this context despite evidence that estrogen can have both neuroprotective as well as neurotoxic properties in the CNS. This workshop will present a general overview of estrogen and the mechanisms by which this hormone influences biological actions including a discussion of estrogen alpha and beta receptor actions and how these actions impact toxicity. The remainder of the session will provide a more focused examination of estrogens' influences in the CNS and will examine its putative antioxidant actions, the role of receptor-mediated actions, direct membrane effects and neurosteroid properties m its neuroprotective actions. The influence of estrogenic chemicals on CNS injury utilizing well-established models of neurotoxic insult as well as their int1uence on brain structure in sexually-dimorphic areas of CNS will be examined. This workshop concerns endocrine disruption, estrogenic chemicals and injury processes.
Keywords
Toxins; Toxicology; Toxic-materials; Hormones; Hormone-activity; Estrogenic-hormones; Neurotoxins; Neurotoxic-effects; Biological-function; Biological-monitoring; Endocrine-system; Endocrine-function
Publication Date
19990301
Document Type
Abstract
Fiscal Year
1999
NTIS Accession No.
NTIS Price
ISSN
1096-6080
NIOSH Division
HELD
Source Name
The Toxicologist. Society of Toxicology 38th Annual Meeting, March 14-18, 1999, New Orleans, Louisiana
State
LA; AR; WV
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