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Acute disruption of cochlear potentials by potassium cyanide.

Authors
Tawackoli-W; Fechter-LD
Source
Toxicologist 1999 Mar; 48(1-S):292
NIOSHTIC No.
20028026
Abstract
Cyanide is present in various environmental settings and is also an occupational hazard for firefighters. Effects and mechanisms of cyanide (CN) toxicity are unclear in hearing 10ss. In this study, adult male Long Evans hooded rats were used to examine the effects of potassium cyanide (KCN). Interactions with noise on cochlear potentials, namely compound action potential (CAP) and cochlear microphonic (CM) were studied. Subjects were injected with KCN (7mg/kg, ip) and compared with controls (saline, ip). CAP sensitivity is dependent upon the function of inner hair cells and spiral ganglion cells. The CM is generated predominantly from outer hair cells. CAP and CM were recorded pre and post administration of KCN. Hearing levels at three frequencies (2 kHz, 12 kHz and 40 kHz) were tested. Blood cyanide levels were measured following KCN administration for a period of 30 min. A temporary threshold shift in both CAP and CM was observed for a period of 5 to 15 min. following KCN administration. Concurrent exposure to KCN and noise (110 dB, broad band) for 2 hours demonstrated no threshold shift in either CAP or CM.
Keywords
Toxins; Toxicology; Toxic-materials; Laboratory-animals; Animal-studies; Statistical-analysis; Analytical-chemistry; Analytical-methods; Chemical-analysis; Dose-response; Exposure-assessment; Hearing-tests; Hearing-disorders; Hearing-protection; Fire-fighters; Fire-fighting; Hearing-protection; Noise-induced-hearing-loss; Synergistic-effects; Cyanides; Ototoxicity
CAS No.
151-50-8
Publication Date
19990301
Document Type
Abstract
Funding Amount
561752
Funding Type
Grant
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003481
ISSN
1096-6080
Priority Area
Disease and Injury: Hearing Loss
Source Name
The Toxicologist. Society of Toxicology 38th Annual Meeting, March 14-18, 1999, New Orleans, Louisiana
State
LA; OK
Performing Organization
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma
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