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Testing of fibrous particles: short-term assays and strategies - report of an ILSI Risk Science Institute working group.

Authors
Bernstein-D; Castranova-V; Donaldson-K; Fubini-B; Hadley-J; Hesterberg-T; Kane-A; Lai-D; McConnell-EE; Muhle-H; Oberdorster-G; Olin-S; Warheit-DB
Source
Inhal Toxicol 2005 Sep; 17(10):497-537
NIOSHTIC No.
20028023
Abstract
Natural and synthetic fibrous materials are widely used in construction, industrial applications, and biomedical devices, as well as in consumer products. Fibrous materials are chemically and structurally diverse; however, for regulatory purposes, fibers are defined on the basis of their size and shape. Widely varied natural and synthetic fibers are currently in commercial use or under development, suggesting the need to understand the potential for adverse health effects if respirable fibers were released during production or application. In contrast to asbestos or synthetic vitreous fibers, other types of fibers have not been systematically assessed for carcinogenicity using lifetime rodent inhalation assays because these tests are technically demanding, expensive, and require large numbers of animals.
Keywords
Fibrous-dusts; Fibrous-bodies; Synthetic-fibers; Respirable-dust; Synthetic-materials; Occupational-health
CODEN
INHTE5
Publication Date
20050901
Document Type
Journal Article
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
0895-8378
NIOSH Division
HELD
Source Name
Inhalation Toxicology
State
WV; OH; IL; RI; DC; NC; NY; DE
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