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A benchmate robot sample preparation workstation in a biological monitoring method for measuring 2,4-D in urine under CLIA '88 criteria.

Authors
Brown-KK
Source
ISLAR '97 Proceedings. 1997 Jan; :374-388
Link
NIOSHTIC No.
20027941
Abstract
A Benchmate Workstation was incorporated into the development of a 2,4-D chlorophenoxy acid herbicide biological monitoring method. Procedures were developed for the translation and optimization of the method algorithim to robotic programs. Manual tube preparation was necessary before and after BenchMate operation. The BenchMate used statistically based experimental designs for method optimization. BenchMate performance monitoring, calibration, and maintenance techniques were developed. The BenchMate provided an electronic mass record of each sample preparation step. This record provided a data "audit trail" for analysis documentation as partial fulfillment of Clinical Laboratory Improvement Amendment of 1988 (CLIA'88) requirements. This BenchMate and gas chromatography with electron capture detector (GC-ECD) method provided sensitive and accurate measurement of 2,4-D concentrations in the urine of agricultural herbicide applicators.
Keywords
Biological-monitoring; Robotics; Monitoring-systems; Sampling; Sample-preparation; Sampling-methods; Gas-chromatography; Agricultural-chemicals; Herbicides
Contact
Analytical Toxicology Section, Applied Biology Branch, Division of Biomedical and Behavioral Sciences, NIOSH, CDC, 4676 Columbia Parkway, MS-C26, Cincinnati, OH 45226
Publication Date
19970101
Document Type
Conference/Symposia Proceedings
Fiscal Year
1997
NTIS Accession No.
NTIS Price
NIOSH Division
DBBS
Source Name
ISLAR '97 Proceedings
State
OH
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