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Mutagenicity of N-OH-MOCA (4-amino-4'-hydroxylamino-bis-3,3'-dichlorodiphenylmethane) and PBQ (2-phenyl-1,4-benzoquinone) in human lymphoblastoid cells.

Authors
Reid-TM; DeBord-DG; Cheever-KL; Savage-RE Jr.
Source
Toxicol Lett 1998 May; 95(3):205-210
NIOSHTIC No.
20027936
Abstract
The genotoxic potential of two occupationally significant chemicals, 4,4'-methylene-bis-2-chloroaniline (MOCA) and 2-phenyl-1,4-benzoquinone (PBQ), was explored by monitoring the induction of mutations at the HPRT locus of AHH-1 human lymphoblastoid cells. Exposure of AHH-1 cells to the putative carcinogenic metabolite of MOCA, N-OH-MOCA, induced a 6-fold increase in mutant frequency and resulted in base pair substitutions primarily at A:T base pairs. In contrast, exposure to PBQ did not result in an increased mutant frequency although this compound was significantly more cytotoxic than N-OH-MOCA at equimolar doses. The induction of mutations at A:T sites by N-OH-MOCA is consistent with the type of DNA damage known to be produced by MOCA and provides a specific marker of genotoxic damage for exposed populations.
Keywords
Mutagens; Mutagenicity; Mutagenesis; Genotoxic-effects; Exposure-assessment
Contact
Division of Biomedical and Behavioral Sciences, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
CODEN
TOLED5
Publication Date
19980501
Document Type
Journal Article
Email Address
tar9@cdc.gov
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0378-4274
NIOSH Division
DBBS
Source Name
Toxicology Letters
State
OH
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