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Survey of sulfur-containing rubber accelerator levels in latex and nitrile exam gloves.

Authors
Depree-GJ; Bledsoe-TA; Siegel-PD
Source
Contact Dermatitis 2005 Aug; 53(2):107-113
NIOSHTIC No.
20027920
Abstract
2-Mercaptobenzothiazole and zinc dialkyldithiocarbamates are commonly used sulfur-containing rubber vulcanization accelerators known to cause allergic contact dermatitis. Exposure to these agents occurs through clothing such as undergarments and shoes, latex medical devices and latex and nitrile gloves. A simple, inexpensive screening method for total sulfur accelerator and a high performance liquid chromatographic speciation method were developed in the present study. These methods were applied to screen and quantify the sulfur accelerator content from 38 brands of 'off-the-shelf' latex and nitrile gloves obtained from commercial vendors. It was found that accelerator levels ranged from not detectable to 7.35 mg/g in the gloves analysed. Brands were found to contain single and multiple accelerator species within the glove. Powdered gloves had significantly higher accelerator levels than powder-free gloves from the same manufacturer; however, these chemical accelerators do not preferentially partition to the powder. The present analytical methodology is suitable for both manufacturing quality validation purposes, as well as for accelerator allergy research.
Keywords
Gloves; Nitriles; Allergic-dermatitis; Contact-dermatitis; Dermatitis; Occupational-exposure; Allergic-reactions; Safety-research; Safety-measures; Safety-clothing
Contact
Paul D. Siegel, PhD, Allergy and Clinical Immunology Branch, M/S L4020, HELD/NIOSH, 1095 Willowdale Road, Morgantown WV 26505-2888, USA
CODEN
CODEDG
CAS No.
149-30-4
Publication Date
20050801
Document Type
Journal Article
Email Address
PSiegel@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0105-1873
NIOSH Division
HELD
Priority Area
Disease and Injury: Allergic and Irritant Dermatitis
Source Name
Contact Dermatitis
State
WV
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