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Intratracheal instillation of welding fumes alters the pulmonary clearance of listeria monocytogenes in the rat.

Authors
Antonini-JM; Charron-TG
Source
Toxicologist 1999 Mar; 48(1-S):131
NIOSHTIC No.
20027838
Abstract
Epidemiological studies have shown an increased incidence of respiratory illness in welders. Stainless steel (SS) welding fumes have been shown to have a greater effect on alveolar macrophage (AM) function than mild steel (MS) fumes. The objective of this study was to evaluate the effects of different welding fumes on the clearance of a bacterial pathogen from the lungs. Fumes were collected during flux-cored manual metal arc (MMA) and gas metal arc (GMA) welding using either S8 or MS consumable electrodes. The fume composition was: 1) GMA.sS: 52.3% Fe, 22.2% Cr, 18.3% Mn, 4.9% Ni, 2.3% Si; 2) GMA-MS: 89.2% Fe, 8.2% Mn, 2.6% Si; 3) MMA-SS.: 22.3% K, 19.4% Fe, 13.1 % Cr, 12.6% Si, 8.2% Ca, 8.0% Mn, 17.4% other. CDNAF rats were dosed intratracheally with saline (control) or the welding samples at a dose of J.O mg/100 g b wt. At 1 and 35 days postinstillation, 5000 Listeria monocytogenes were intratracheally instilled into the treated animals. Five days after intratracheal exposure to L. monocytogenes, the lungs and spleen were removed, homogenized, and cultured quantitatively on Brain Heart Infusion agar at 370 C. Colony forming units (CFUs) were counted after an overnight incubation. After a 1 day fume treatment, all three we1ding samples caused a significant decrease (p
Keywords
Animal-studies; Animals; Laboratory-animals; Chemical-analysis; Analytical-chemistry; Analytical-methods; Stainless-steel; Respiratory-system-disorders; Respiratory-irritants; Pulmonary-disorders; Pulmonary-system-disorders; Welding-industry; Welding; Welders; Welders-lung
Publication Date
19990301
Document Type
Abstract
Fiscal Year
1999
NTIS Accession No.
NTIS Price
ISSN
1096-6080
NIOSH Division
HELD
Source Name
The Toxicologist. Society of Toxicology 38th Annual Meeting, March 14-18, 1999, New Orleans, Louisiana
State
WV
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