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An approach to area sampling and analysis for total isocyanates in workplace air.

Authors
Key-Schwartz-R; Tucker-SP
Source
Am Ind Hyg Assoc J 1999 Mar/Apr; 60(2):200-207
NIOSHTIC No.
20027767
Abstract
An approach to sampling and analysis for total isocyanates (monomer plus any associated oligomers of a given isocyanate) in workplace air has been developed and evaluated. Based on a method developed by the Occupational Health Laboratory, Ontario Ministry of Labour, Ontario, Canada, isocyanates present in air are derivatized with a fluorescent reagent, tryptamine, in an impinger and subsequently analyzed via high-performance liquid chromatography (HPLC) with fluorescence detection. Excitation and emission wavelengths are set at 275 and 320 nm, respectively. A modification to the Ontario method was made in the replacement of the recommended impinger solvents (acetonitrile and 2,2,4-trimethylpentane) with dimethyl sulfoxide (DMSO). DMSO has the advantages of being compatible with reversed-phase HPLC and not evaporating during sampling, as do the more volatile solvents used in the Ontario method. DMSO also may dissolve aerosol particles more efficiently during sampling than relatively nonpolar solvents. Several formulations containing diisocyanate prepolymers have been tested with this method in the laboratory. This method has been issued as National Institute for Occupational Safety and Health (NIOSH) Method 5522 in the first supplement to the fourth edition of the NIOSH Manual of Analytical Methods. This method is recommended for area sampling only due to possible hazards from contact with DMSO solutions containing isocyanate derivatives. The limits of detection are 0.1 g/sample for 2,4-toluene diisocyanate, 0.2 g/sample for 2,6-toluene diisocyanate, 0.3 g/sample for methylene bisphenyl diisocyanate, and 0.2 g/sample for 1,6-hexamethylene diisocyanate.
Keywords
Sampling; Sampling-equipment; Sampling-methods; Analytical-chemistry; Analytical-methods; Analytical-processes; Isocyanates; Workplace-monitoring; Workplace-studies; Fluorescence-spectrometry; Chromatographic-analysis; Statistical-analysis
CODEN
AIHAAP
CAS No.
75-05-8; 540-84-1; 67-68-5
Publication Date
19990301
Document Type
Journal Article
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0002-8894
NIOSH Division
DPSE
Source Name
American Industrial Hygiene Association Journal
State
OH
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