Measuring endocrine profiles of women in field studies.
Kesner-JS; Knecht-EA; Krieg-EF Jr.
Scand J Work, Environ & Health 1999 Dec; 25(Suppl 1):17-19
Improved methods are needed to evaluate the effects of occupational and environmental hazards on the reproductive health of human female populations. This communication describes highly specific, sensitive, and reliable time-resolved fluorescence immunoassays for measuring luteinizing hormone (LH) and follicle-stimulating hormone (FSH), estrone 3-glucuronide (E13G), and pregnanediol 3-glucuronide (Pd3G) in urine, a fluid that is convenient and painless to collect serially from large populations. Furthermore, some of the technical issues relevant to the successful application of these measurements to field studies are discussed.
Occupational-hazards; Occupational-health; Occupational-exposure; Environmental-health; Environmental-hazards; Environmental-exposure; Women; Reproductive-system; Reproductive-system-disorders; Reproductive-hazards; Reproduction; Reproductive-effects; Fluorescence-spectrometry; Estrogenic-hormones; Gonadotropic-hormones;
Author Keywords: estrogens; follicle-stimulating hormone; luteinizing hormone; menstrual cycle; progestins; urine
Dr James S Kesner, Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-C23, Cincinnati, OH 45226, USA
Scandinavian Journal of Work, Environment and Health