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Ethical issues in the use of genetic markers in occupational epidemiologic research.

Authors
Schulte-PA; Lomax-GP; Ward-EM; Colligan-MJ
Source
J Occup Environ Med 1999 Aug; 41(8):639-646
NIOSHTIC No.
20027710
Abstract
This review was conducted to characterize the nature of contemporary occupational epidemiologic research involving genetic markers, consider how genetic information is unique with regard to its social applications, and examine some of the ethical dilemmas that may arise over the course of studies. We have reviewed the literature and the lessons from our experience in conducting occupational epidemiologic research involving genetic markers. This review describes how occupational epidemiologic studies differ from other epidemiologic studies on issues of participation, confidentiality, and the history of including genetic markers. Of primary concern in occupational studies are genes that have multiple alleles and are sometimes referred to as "metabolic polymorphisms." They generally do not confer risk on their own but rather only in combination with a specific exposure. There is a need for a clear policy and guidelines for the conduct of occupational epidemiologic studies using genetic material. This policy should address all of the steps in study design, implementation, interpretation, and communication of results.
Keywords
Epidemiology; Genetic-factors; Genetic-engineering; Genetics; Occupational-diseases; Occupational-exposure; Occupational-hazards; Occupational-health; Risk-analysis; Risk-factors
Contact
Paul A. Schulte, PhD, Education and Information Division, NIOSH, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998
CODEN
JOEMFM
Publication Date
19990801
Document Type
Journal Article
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
8
ISSN
1076-2752
NIOSH Division
EID
Source Name
Journal of Occupational and Environmental Medicine
State
OH
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