Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Quantitative measure of genetic differences in susceptibility to noise-induced hearing loss in two strains of mice.

Authors
Davis-RR; Cheever-ML; Kreig-EF; Erway-LC
Source
Hear Res 1999 Aug; 134(1-2):9-15
NIOSHTIC No.
20027665
Abstract
The CBA/CaJ (CB) and C57BL/6J (B6) inbred strains of mice were exposed for 1 h to noise intensities between 98 and 119 dB SPL. Previous studies indicated that the B6 mice exhibited permanent threshold shifts (PTS) after 1 h exposure to 110 dB, whereas the CB mice did not exhibit any PTS. These differences in susceptibility to noise-induced hearing loss (NIHL) appear to be due to a gene for age-related hearing loss (AHL). The current study was designed to determine dose-response curves for NIHL over the ranges of intensities of noise that would characterize the B6 and CB inbred strains of mice. Because of the considerable differences in sensitivity to NIHL, the noise exposures for the two strains overlapped only at 110 and 113 dB. Nevertheless, the two strains exhibited two different dose-response curves, offset and with different slopes. We postulate that the B6 strain of mice exhibits a more linear increase for PTS from 98-113 dB, consistent with incremental effects on some metabolic physiological mechanism(s); the abrupt transition in NIHL between 113 and 116 dB for the CB mice is consistent with an ototraumatic structural injury.
Keywords
Noise-induced-hearing-loss; Noise-exposure; Noise-analysis; Noise-protection; Hearing-loss; Hearing-disorders; Hearing-protection; Laboratory-animals; Laboratory-testing; Age-factors; Workplace-studies; Statistical-analysis
CODEN
HERED3
Publication Date
19990801
Document Type
Journal Article
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0378-5955
NIOSH Division
DBBS
Source Name
Hearing Research
State
OH; FL
TOP