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Comparative toxicity of nanomaterials in vitro and in vivo.

Authors
Shvedova-AA; Murray-AR; Johnson-VJ; Gorelik-O; Arepalli-S; Hubbs-A; Mercer-RR; Baron-P; Maynard-AD; Kagan-VE; Potapovich-AI; Castranova-V; Kisin-E
Source
Abstr Pap - Am Chem Soc 2005 Mar; 229(Part 1):014-IEC
NIOSHTIC No.
20027576
Abstract
Society is currently amidst with revolutionary developments of remarkable new technologies based on novel applications of nanomaterials. A comparative in vitro study of nanosized particles revealed dose-dependent formation of granulomatous bronochointerstitial pneumonia, fibrosis, and changed pulmonary function in C57BL/6 mice. Administration of CNT to mice also resulted in a dose-dependent augmentation of biomarkers of inflammation quantified by lavage cell counts, total protein, lactate dehydrogenase and glutamyltranspeptidase activities in BAL fluids and accumulation of pro-inflammatory and pro-fibrotic cytokines. Overall, our data suggest that in vivo exposure to CNT leads to pulmonary toxicity realized through the synergized interactions of inflammatory response and oxidative stress culminating in the development of multifocal granulomatous pneumonia and fibrosis. The value of both approaches will be discussed in line with assessment of adverse outcomes of nanomaterials.
Keywords
In-vitro-studies; In-vivo-studies; Cytotoxins; Cytotoxic-effects; Cytotoxicity; Laboratory-animals; Animals; Animal-studies; Exposure-levels; Exposure-assessment; Fibrosis; Biomarkers; Pulmonary-system-disorders; Respiratory-system-disorders; Nanotechnology
CODEN
ACSRAL
Publication Date
20050313
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
2005
NTIS Accession No.
NTIS Price
ISSN
0065-7727
NIOSH Division
HELD; OD; DART
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Abstracts of papers - American Chemical Society
State
WV; TX; OH; PA
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