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Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos.

Authors
Greenlee-AR; Ellis-TM; Berg-RL
Source
Environ Health Perspect 2004 May; 112(6):703-709
NIOSHTIC No.
20027492
Abstract
Occupational exposures to pesticides may increase parental risk of infertility and adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, and congenital anomalies. Less is known about residential use of pesticides and the risks they pose to reproduction and development. In the present study we evaluate environmentally relevant, low-dose exposures to agrochemicals and lawn-care pesticides for their direct effects on mouse preimplantation embryo development, a period corresponding to the first 5-7 days after human conception. Agents tested were those commonly used in the upper midwestern United States, including six herbicides [atrazine, dicamba, metolachlor, 2,4-dichlorophenoxyacetic acid (2,4-D)], pendimethalin, and mecoprop), three insecticides (chlorpyrifos, terbufos, and permethrin), two fungicides (chlorothalonil and mancozeb), a desiccant (diquat), and a fertilizer (ammonium nitrate). Groups of 20-25 embryos were incubated 96 hr in vitro with either individual chemicals or mixtures of chemicals simulating exposures encountered by handling pesticides, inhaling drift, or ingesting contaminated groundwater. Incubating embryos with individual pesticides increased the percentage of apoptosis (cell death) for 11 of 13 chemicals (p
Keywords
Agriculture; Agricultural-industry; Pesticides; Occupational-exposure; Risk-factors; Risk-analysis; Pregnancy; Environmental-exposure; Herbicides; Insecticides; Fungicides; Fungi; In-vitro-studies
Contact
A.R. Greenlee, Reproductive Toxicology Laboratory, Marshfield Clinic Research Foundation, 1000 North Oak Ave., Marshfield, WI 54449 USA
CODEN
EVHPAZ
CAS No.
1912-24-9; 1918-00-9; 94-75-7; 93-65-2; 2921-88-2; 52645-53-1; 1897-45-6; 8018-01-7; 6484-52-2
Publication Date
20040501
Document Type
Journal Article
Email Address
anne@mcrf.mfldclin.edu
Funding Amount
1155892
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-CCU-514436
Issue of Publication
6
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
WI
Performing Organization
Marshfield Medical Research & Education Foundation, Marshfield, Wisconsin
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