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New insights into the role of nuclear factor-KB, a ubiquitous transcription factor in the initiation of diseases.

Authors
Chen-F; Castranova-V; Shi-X; Demers-LM
Source
Clin Chem 1999 Jan; 45(1):7-17
NIOSHTIC No.
20027447
Abstract
Nuclear factor-B (NF-B) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-B is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases.
Keywords
Genes; Gene-mutation; Genetic-disorders; Genetic-engineering; Genetic-factors; Cancer; Cancer-rates; Carcinogenesis; Carcinogens; Statistical-analysis; Heredity
Contact
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
CODEN
CLCHAU
Publication Date
19990101
Document Type
Journal Article
Email Address
lfd3@cdc.gov
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0009-9147
NIOSH Division
HELD
Source Name
Clinical Chemistry
State
WV; PA
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