Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

2,4-Dichlorophenoxyacetic acid residues in semen of Ontario farmers.

Authors
Arbuckle-TE; Schrader-SM; Cole-D; Hall-JC; Bancej-CM; Turner-LA; Claman-P
Source
Reprod Toxicol 1999 Nov; 13(6):421-429
NIOSHTIC No.
20027404
Abstract
Although paternal exposures to environmental toxicants probably play a role in adverse pregnancy outcomes, few data are available on the extent of this exposure. One semen and two 24-h urine samples were collected from 97 Ontario farmers who had recently used the phenoxy herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and/or MCPA ([4-chloro-2-methylphenoxy] acetic acid). Both samples were analyzed for 2,4-D using an immunoassay-based technique. Approximately 50% of the semen samples had detectable levels of 2,4-D (=5.0 ppb (ng/mL)). Semen levels of 2,4-D were correlated more closely with the second of the two urine samples. Although several studies have measured 2,4-D in the urine of applicators, this study is the first to attempt to measure 2,4-D levels in semen. As these pesticides can be excreted in the semen, they could be toxic to sperm cells and be transported to the woman and developing embryo/fetus. Further research is needed to understand how pesticide handling practices can affect semen pesticide residues and the relationship between the levels observed and reproductive health.
Keywords
Reproductive-system-disorders; Reproductive-system; Agricultural-workers; Agricultural-chemicals; Agricultural-industry; Herbicides; Exposure-assessment; Families; Biological-monitoring; Biological-effects; Urinalysis; Urogenital-system-disorders; Urogenital-system
CODEN
REPTED
CAS No.
94-75-7
Publication Date
19991101
Document Type
Journal Article
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0890-6238
NIOSH Division
DART
Source Name
Reproductive Toxicology
State
OH
TOP