Surface and skin decontamination of aliphatic isocyanates: a field study.
Liu-Y; Stowe-MH; Bello-D; Sparer-JA; Lutgendorf-C; Daly-C; Ullman-S; Youngs-F; Abrahim-K; Fleming-CE; Collin-Hanson-I; Cartmel-B; Gore-R; Boeniger-MF; Woskie-SR; Cullen-MR; Redlich-CA
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005. Morgantown, WV: National Institute for Occupational Safety and Health, 2005 Jun; :1-3
Surface contamination and skin exposure to isocyanates may cause dermal sensitization leading to asthma. Surface and skin decontamination using commercial products may provide effective measures to reduce the risk of skin exposure to isocyanates. However, little is known about the efficacy of various products in decontaminating aliphatic isocyanates. As part of a large interventional study to reduce isocyanate exposures in the auto body repair and refinishing industry (the Safe Methods for Autobody Shop Health or SMASH Study), we have conducted a series of studies to evaluate the efficacy of various commercial products, including a laboratory experimental study to evaluate the reaction time and mechanical removal efficiency, an in vitro study using guinea pig skin to evaluate the effects of solvents and isocyanate residence time on skin exposure, and this field study to assess the efficacy in auto body shop settings. The objectives of this study were to 1) qualitatively and quantitatively assess the efficacy of surface decontamination products in removing aliphatic isocyanates, and 2) qualitatively and quantitatively assess the efficacy of skin cleansers in removing aliphatic isocyanates.
Respiratory-system-disorders; Exposure-assessment; Skin-absorption; Skin-exposure; Skin-irritants; Skin-protection; Isocyanates; In-vitro-studies; In-vitro-study; Animal-studies; Animals; Soap-products; Occupational-exposure; Occupational-hazards; Decontamination
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005