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Analytical chemistry of metalworking fluids for dermal and inhalation toxicology studies.

Authors
Brown-KK; Arnold-JE
Source
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005. Morgantown, WV: National Institute for Occupational Safety and Health, 2005 Jun; :1-2
Link
NIOSHTIC No.
20027227
Abstract
In support of a National Toxicology Program (NTP) study on metalworking fluids (MWF), NIOSH was provided samples of the fluids being tested in that study [NTP 2004]. Aliquots of these fluids were shared with NIOSH researchers for local lymph node assays (LLNA), skin penetration tests, and chemical analyses. Currently, there is no NIOSH method or literature method for the separation and identification of the major components in a MWF mixture. A method for their analysis is described and preliminary results are reported. The analytical results of this method will provide data to researchers of the NTP, LLNA, and dermal penetration studies and likely impact their conclusions. Liquid and gas phase chromatographic methods were used to characterize the composition of these complex mixtures. The major components in MWFs were separated by high performance liquid chromatography (HPLC) and detected by both ultraviolet (UV) absorption and evaporative light scattering detection (ELSD). The UV detector is a non-destructive specific detector that does not detect all the components, while the ELSD is a destructive "universal detector" capable of detecting most compounds. The ELSD response is a function of analyte mass, and therefore peak areas in a chromatogram reflect the relative abundance of a component in the MWF. The ELSD was used to locate the major components in a MWF with respect to UV-ELSD active internal standards.
Keywords
Metal-workers; Metallic-compounds; Metallic-fumes; Metallic-poisoning; Metallic-poisons; Skin-tests; Skin-irritants; Skin-exposure; Skin-disorders; Skin-diseases; Skin-absorption; Skin-cancer; Chromatographic-analysis; Absorption-rates; Statistical-analysis; Metalworking-fluids; Metalworking; Metalworking-industry
CAS No.
102-71-6; 59-50-7; 57-10-3
Publication Date
20050612
Document Type
Abstract
Fiscal Year
2005
NTIS Accession No.
NTIS Price
NIOSH Division
DART
Source Name
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005
State
OH; WV
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