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Laboratory evaluation and field testing of a collection method for 1-bromopropane in exhaled breath.

Authors
Hanley-KW; Sanderson-WT; Grote-A
Source
Applying Biomarkers to Occupational Health Practice, Santa Fe, NM, March 24-25, 2003. Atlanta, GA: Centers for Disease Control, 2003 Mar; :9
Link
NIOSHTIC No.
20027212
Abstract
1-Bromopropane (1-BP) has been marketed as an alternative for ozone-depleting solvents and is in adhesives, cleaning solvents, and aerosol products. Toxicity of 1-BP is poorly understood, but it may be a neurologic, reproductive, and hematologic toxin. Sparse exposure information has prompted NIOSH to conduct a multi-industry study using air, exhaled breath, and urinary metabolite measurements. Exhaled breath analysis can be a powerful, non-invasive tool which is affected by inhalation and dermal exposures. Breath sampling methods must be accurate, sensitive, and unaffected by water vapor to measure trace levels consistently without contamination or deterioration. This study evaluated a practical breath collection method for 1-BP analysis conducted at an off-site laboratory with proper quality control.
Keywords
Analytical-methods; Analytical-chemistry; Sampling-methods; Biomarkers; Adhesives; Cleaning-compounds; Aerosol-particles; Aerosols; Chromatographic-analysis; Neurotoxic-effects; Reproductive-system-disorders; Hematopoietic-system
CAS No.
106-94-5
Publication Date
20030324
Document Type
Abstract; Conference/Symposia Proceedings
Fiscal Year
2003
NTIS Accession No.
NTIS Price
NIOSH Division
DART; DSHEFS
Source Name
Applying Biomarkers to Occupational Health Practice, Santa Fe, NM, March 24-25, 2003
State
OH; NM; IA
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