Exposure to diesel exhaust and risk of lung cancer in the trucking industry.
Yiin-JH; Stayner-LT; Steenland-NK; Bailey-CR; Smith-RJ; LeMasters-GK
Society for Risk Analysis 2003 Annual Meeting. Bridging Risk Divides, Baltimore, Maryland, December 7-10, 2002. McLean, VA: Society for Risk Analysis, 2003 Dec; :120
A quantitative exposure-response analysis of diesel exhaust and lung cancer among workers in the trucking industry was conducted with a new exposure model developed by the Environmental Protection Agency (EPA). To estimate past exposures, EPA generated 2,500 diesel particulate matters (DPM) for each calendar year from 1950 to 1990 and for each of the four exposed job categories plus the nonexposed. Logistic regression relating lung cancer risk and cumulative diesel particulate matters and adjusting for smoking status, age at death, and reported asbestos exposure was used. The means of the 2,500 annual job-specific DPM were used for exposure estimates in the exposure-response analyses. As a sensitivity analysis, Monte Carlo simulations using the full distributions of these DPM were conducted. Using the new exposure model, the estimated cumulative exposures to diesel exhaust for all job categories were significatnly lower than those previously estimated by Steenland et al. The estimated excess risks, however, were similar. For a male truck driver exposed to 5 microg/m3 of diesel particulate mass, the estimated lifetime excess risk of lung cancer in the current analysis was 1.9% compared to 1.6% in the previous study.
Risk-analysis; Epidemiology; Risk-factors; Quantitative-analysis; Exposure-assessment; Diesel-exhausts; Diesel-emissions; Carcinogens; Epidemiology; Lung-cancer; Truck-drivers; Trucking; Exhaust-gases; Statistical-analysis; Transportation-industry; Transportation-workers; Particulate-dust; Particulates; Dusts; Aerosols; Aerosol-particles; Pulmonary-system-disorders; Respiratory-system-disorders
Abstract; Conference/Symposia Proceedings
Society for Risk Analysis 2003 Annual Meeting Bridging Risk Divides, Baltimore, Maryland, December 7-10, 2002